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SLE anti-BC abs in neurons. Delivery of BC RNAs to synapto-dendritic domains requires transport factor hnRNP A2. The factor interacts with targeting-determinant GA motifs contained within BC RNA 5′ stem–loop domains. SLE anti-BC IgGs bind to the same motif structures, displacing hnRNP A2 from BC RNAs and as a result causing impaired dendritic delivery.
