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. 2019 Sep 25;39(39):7759–7777. doi: 10.1523/JNEUROSCI.1657-18.2019

Figure 8.

Figure 8.

Dendritic transport of human BC200 RNA: impairment after coinjection with SLE anti-BC IgGs. Coinjection was performed, as described for Figure 7, with IgG HS4 (A, B), IgG SLE S1 (C, D), or IgG MS1 (E, F). Dark-field photomicrographs (A, C, E) are accompanied by corresponding phase-contrast photomicrographs (B, D, F). Scale bar, 50 μm. Number of cells analyzed: A, B, 9 neurons, 33 dendrites; C, D, 8 neurons, 28 dendrites; and E, F, 7 neurons, 27 dendrites. Quantitative analysis (G) indicates that IgG SLE S1, but not IgG HS4 or IgG MS1, significantly reduces dendritic delivery of BC200 RNA.