Figure 5.
Histology and immunohistochemical analysis of microvascular thrombosis in mouse tissues. Representative images of major organ tissues from Adamts13−/−cfhW/R at the age of 3 months being euthanized, including brain (A-C), heart (D-F), intestine (G-I), kidney (J-L), liver (M-O), and lung (P-R), stained with H&E (left column), anti-β3 IgG (middle column), and anti-fibrinogen (Fgn) IgG (right column) as described in “Methods.” Arrow indicates the presence of occlusive and platelet-rich microvascular thrombus. Scale bar, 100 μm.