Table 1.

Expected and obtained distribution of mice with various genotypes

Genotype	N	Expected, %	Observed, %
a13−/−cfhW/W × a13−/−cfhW/R
a13−/−cfhW/W	60	50	62.5*
a13−/−cfhW/R	36	50	37.5*
a13−/−cfhW/R × a13−/−cfhW/R
a13−/−cfhW/W	64	25	32.5
a13−/−cfhW/R	89	50	45.2
a13−/−cfhR/R	44	25	22.3

A Student t test was performed for comparing the difference between the percent observed and expected. The null hypothesis value (percentage expected) is based on the Mendelian distribution.

a13^−/−, Adamts13 null; cfh, complement factor H; cfh^W/W, cfh^W/R, and cfh^R/R represent wild-type, heterozygous, and homozygous mutations in the gene encoding cfh at the position of 1206.

^*P < .05.