Figure 6.

STAT3 promoted invasion in MEC1 and CCL cancerous cells through increasing SMYD3 expression. Cells were plated into multi-well transwell plates and divided into four groups to apply four different treatments: NC group, negative control, SMYD3 knockdown group, indicating transfection with siRNA1-SMYD3, STAT3 overexpression group, indicating transfection with pcDNA3.1-STAT3 vectors and combination group, indicating transfection with siRNA-SMYD3 and pcDNA3.1-STAT3. A, B – Cell invasion ability of MEC1 was investigated in different transfection groups. C, D – Cell invasion ability of CCL was investigated in different transfection groups

Data are means ± SD. **P < 0.01, compared with NC group.