TABLE 3.
Minimum Inhibitory Concentration data and antimicrobial susceptibility of Acinetobacter baumannii from three tertiary care hospitals in Mexico.
| Drug class | Antimicrobial agent | MIC range CLSI/2018 | HCG (n = 202) | HRGIZ (n = 42) | HGM-P (n = 8) | ||||||||
| S | I | R | MIC50 (μg/mL) | MIC90 (μg/mL) | R% | MIC50 (μg/mL) | MIC90 (μg/mL) | R% | MIC50 (μg/mL) | MIC90 (μg/mL) | R% | ||
| Aminoglycosides | Amikacin | ≤16 | 32 | ≥64 | 64 | >128 | 76.2 | 128 | 128 | 78.6 | >128 | >128 | 87.5 |
| Lipopeptides | Colistin | ≤2 | – | ≥4 | 0.5 | 2 | 5.4 | 0.5 | 2 | 4.8 | 1 | 1 | 12.5 |
| Cephems | Cefepime | ≤8 | 16 | ≥32 | 128 | >128 | 88.2 | 128 | >128 | 100 | 64 | 128 | 75 |
| Carbapenems | Imipenem | ≤2 | 4 | ≥8 | 64 | 128 | 97.5 | 128 | 128 | 90.5 | >128 | >128 | 75 |
| Meropenem | ≤2 | 4 | ≥8 | 128 | >128 | 97.5 | 128 | 128 | 97.6 | >128 | >128 | 75 | |
| Penicillins | Piperacillin | ≤16 | 32–64 | ≥128 | >256 | >256 | 97.5 | >256 | >256 | 100 | >256 | >256 | 75 |
| Tetracyclines | Tetracycline | ≤4 | 8 | ≥16 | 32 | >128 | 82.2 | >128 | >128 | 100 | 16 | ≥128 | 62.5 |
HCG, Hospital Civil de Guadalajara. HRGIZ, Hospital Regional General Ignacio Zaragoza, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado. HGM-P, Hospital General de México, Pediatric ward. Dilution method in MH agar was used to determine MIC to piperacillin, cefepime, imipenem, meropenem, amikacin, and tetracycline. Broth microdilution method was used to determine colistin MIC.