Table 2.

Clinical chemistry data for mice in the 90-day gavage study of CYN^a

Dose (μg/kg)	0	75	150	300
Male
n	10	10	9	10
ALP (IU/L)	38.3 ± 3.3	31.6 ± 0.7	35.4 ± 2.7	46.1 ± 5.0
ALT (IU/L)	68.6 ± 7.3	56.5 ± 5.4	63.2 ± 11.9	112.7 ± 14.0*
TBA (μmol/L)	0.96 ± 0.21	1.05 ± 0.20	0.98 ± 0.13	1.26 ± 0.29
BUN (mg/dL)	23.6 ± 2.3	17.8 ± 0.8*	16.8 ± 1.7**	16.2 ± 0.9**
Creatinine (mg/dL)	0.16 ± 0.02	0.10 ± 0.00	0.16 ± 0.02	0.15 ± 0.02
Glucose (mg/dL)	174.4 ± 8.1	184.4 ± 8.3	167.2 ± 7.1	170.4 ± 8.4
Albumin (g/dL)	2.8 ± 0.08	3.1 ± 0.04*	2.9 ± 0.08	2.9 ± 0.06
Total protein (g/dL)	5.5 ± 0.2	5.5 ± 0.1	5.4 ± 0.2	5.2 ± 0.1
Cholesterol (mg/dL)	148.7 ± 12.4	130.3 ± 6.4	114.3 ± 5.1**	95.7 ± 5.7**
Triglycerides (mg/dL)	168.8 ± 22.3	145.6 ± 18.9	152.8 ± 29.9	99.5 ± 9.7*
Female
n	9	10	10	10
ALP (IU/L)	57.3 ± 5.6	48.0 ± 3.1	55.4 ± 8.2	78.9 ± 5.7*
ALT (IU/L)	91.7 ± 38.6	194.4 ± 116.6	112.7 ± 44.5	83.6 ± 11.5
TBA (μmol/L)	2.93 ± 0.45	3.93 ± 1.68	2.94 ± 0.66	2.87 ± 0.46
BUN (mg/dL)	21.9 ± 0.7	20.6 ± 1.0	16.4 ± 1.0**	21.4 ± 1.2
Creatinine (mg/dL)	0.17 ± 0.02	0.18 ± 0.01	0.13 ± 0.02	0.18 ± 0.02
Glucose (mg/dL)	165.9 ± 5.1	176.0 ± 10.5	159.7 ± 4.9	160.9 ± 6.4
Albumin (g/dL)	3.1 ± 0.06	3.4 ± 0.06*	3.2 ± 0.03	3.1 ± 0.09
Total protein (g/dL)	5.3 ± 0.1	5.4 ± 0.1	5.3 ± 0.1	5.2 ± 0.1
Cholesterol (mg/dL)	113.8 ± 10.1	89.2 ± 7.3	99.1 ± 7.5	91.4 ± 8.7
Triglycerides (mg/dL)	204.7 ± 21.8	206.4 ± 28.7	245.3 ± 29.1	226.0 ± 25.4

^aData are given as mean ± standard error; abbreviations: ALP = alkaline phosphatase, ALT = alanine aminotransferase, TBA = total bile acids, BUN = blood urea nitrogen.

^*Significant differences (P ≤0.05) from control using Wilcoxon and Kruskal-Wallis tests.

^**Significant differences (P ≤0.01) from control using Wilcoxon and Kruskal-Wallis tests.