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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: Mol Pharm. 2018 May 16;15(6):2069–2083. doi: 10.1021/acs.molpharmaceut.8b00319

Figure 1: Elevated ECM enables tumor promoting activities.

Figure 1:

ECM in tumors causes: 1. Increased angiogenesis to supply nutrients for the growing tumor; 2. Growth factor signaling leading to cell proliferation; 3. Recruitment of anti-inflammatory, protumor immune cells; and 4. Creating of a path for metastatic cells to extravasate from the primary tumor.