Table 1:
Particle | Amount of enzyme | Duration of treatment | Route of Injection | Source | Tumor Type | Effect | Change in ECM | Ref |
---|---|---|---|---|---|---|---|---|
IgG | 2000 µg | 1 hour | Intratumoral | Bacterial collagenase (Sigma) | Mu89 melonoma (dorsal skinfold chamber) | 1.2X increase in percentage of particles undergoing fast diffusion | N/A | 46 |
IgG | 30 mg | 24 hour | Intratumoral | Clostridium (biochemical corp) | HSTS sarcoma, U87 (dorsal skinfold chamber) | 2X increase in diffusion coefficient | N/A | 47 |
150 kDa Dextran | 100 µg | 24 or 48 hour | Tail vein | Clostridiopeptidase A (Sigma) | OHS osteosarcoma (dorsal skinfold chamber) | 2X increase in diffusion coefficient | N/A | 48 |
500 kDa Dextran, Albumin | 2000 µg | 3 hour | Intratumoral | Bacterial collagenase (Sigma) | B16F10 melanoma (shoulder blades) | 2X increase in tumor diffusion coefficient (.5 mm depth). 10X increase in tumor diffusion coefficient (2 mm depth) |
Reduction by western blot | 49 |