Table 6:
Particle | Duration | Source | Tumor Type | Effect | Change in ECM | Ref |
---|---|---|---|---|---|---|
HS Vector MGH2 | 7 days | MMP-1 and MMP-8 expressing HSTS26T | HSTS26T Sarcoma | 5–10X increase in viral immunostaining at tumor center 1.3X decrease in tumor growth |
No detectable change in imaged tumor SHG intensity | 101 |
Adwt300 virus | Up to 50 days | MMP-8 expressing A549 and BxPC-3 cells | A549 alveolar adenocarcinoma BxPC-3 pancreatic cancer |
Increase in viral distribution by viral immunostaining (unquantified) 3X decrease in tumor volume (day 30–50) Complete survival of animals (BxPC-3) |
3X decrease in visible collagen by histology | 102 |
HSV-eGFP | 21 days | MMP-9 expressing SK-N-AS | SK-N-AS Neuroblastoma | 3X increase in GFP positive cells (Spheroids) Increase tumor vector distribution by viral immunostaining (unquantified) |
N/A | 112 |