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. 2019 Sep 6;6(9):1807–1814. doi: 10.1002/acn3.50885

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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Segmentation errors–Examples of segmentation errors by FreeSurfer (top row) and NeuroQuant (bottom row), circled for emphasis. Transparent color overlays represent segmentation labels. Note that that structure colors differ between FreeSurfer and NeuroQuant. (A) FreeSurfer erroneously labeled the anterior right hippocampus as amygdala (blue), and labeled the lateral left anterior hippocampus as amygdala (B) FreeSurfer again labeled the right anterior hippocampus as amygdala (blue), and labeled the left mesial part of the anterior hippocampus as amygdala. (C) Here, FreeSurfer correctly segmented the right hippocampus (tan), but on the left side labeled a portion of the lateral hippocampus as amygdala. The FreeSurfer segmentation errors in (A–C) represent undersegmentation of the hippocampus and would produce artificially low hippocampal volumes. (D) NeuroQuant incorrectly labels the right anterior hippocampus as amygdala (blue), and labels the lateral anterior left hippocampus as cortex (red). (E) Here, NeuroQuant labels both the left and right lateral portions of the hippocampus (tan) as cortex (red). (F) NeuroQuant correctly identifies the left hippocampus (tan), amygdala (blue), and temporal neocortex (red) but erroneously labels the right lateral portion of the anterior hippocampus as amygdala (blue). The NeuroQuant errors in (D–F) represent undersegmentation of the hippocampus and would also produce artificially low hippocampal volumes.