Table 2.
Comparison of data on motor episodes during REM sleep and markers of degeneration obtained in the two groups of patients.
| iRBD (n = 30) | RBD‐NT1 (n = 17) | P | q | |
|---|---|---|---|---|
| Mean ± SD or % | Mean ± SD or % | |||
| Motor episodes in REM sleep | ||||
| Presence of simple motor episodes | 93.1% | 94.1% | 0.893 | |
| Number of simple episodes | 9.3 ± 7.35 | 12.4 ± 12.65 | 0.659 | |
| Intraindividual stereotypy of events | 40.7% | 75% | <0.05 | |
| Presence of complex motor episodes | 58.6% | 70.6% | 0.417 | |
| Number of complex episodes | 5.2 ± 3.91 | 5.6 ± 4.98 | 0.929 | |
| Mean duration of complex episodes, seconds | 20.7 ± 16.30 | 15.1 ± 18.91 | 0.071 | |
| Intraindividual stereotypy of events | 37.5% | 66.7% | 0.127 | |
| Violent/energetic pattern | 27.6% | 5.9% | 0.073 | |
| Episodes occurring in the 2nd half of the night | 93.8% | 42.3% | <0.05 | <0.05 |
| Episodes occurring in the 1st and 2nd half of the night | 6.2% | 57.7% | ||
| Motor episodes in NREM sleep | ||||
| Simple motor episodes | 44.8% | 76.5% | <0.05 | |
| Number of episodes | 6.8 ± 6.40 | 21.5 ± 15.52 | <0.005 | <0.05 |
| Intraindividual stereotypy of events | 33.3% | 76.9% | <0.05 | |
| Distribution of motor episodes | ||||
| N1 | 46.6% | 7.7% | <0.001 | <0.005 |
| N1‐N2 | 46.2% | 7.7% | ||
| N2‐N3 | 7.7% | 3.8% | ||
| N1‐N2‐N3 | 0 | 53.8% | ||
| Presence of complex motor episodes | 0 | 15% | 0.054 | |
| Markers of neurodegeneration | ||||
| Pathological DaTscan§ | 36.7% | 13.3% | 0.104 | |
| Pathological neuropsychological tests | 3.3% | 0 | 0.475 | |
| Single deficits at neuropsychological tests | 50% | 20% | 0.053 | |
| Positive skin biopsy for p‐α‐syn | 86.7% | 0 | <0.0001 | <0.0001 |
N1, N2, N3, stage 1, 2 and 3 of NREM sleep; EF, executive function; VF, verbal fluency; VL, verbal logic; VM, verbal memory; VSA, visuo‐spatial abilities, p‐α‐syn, phosphorylated alpha synuclein; q, FDR‐adjusted P‐values. Significant P values are in bold. § = 2 NT1 patients = putamen one‐side; 11 iRBD patients = # 5 putamen one‐side; # 1 caudate one side; # 1 putamen and caudate = # 3 = putamen bilaterally; # 1 caudate bilaterally.