Table 2.
The top five gene sets resulting from GSEA analysis differential expression results in the brain and blood.
| Gene set name | Set size | Genes present (%) | NES | FWER P‐value |
|---|---|---|---|---|
| In the brain | ||||
| TNF‐α signaling via NF‐κB | 108 | 60 (55.56%) | 2.9711735 | <2.10‐4 |
| P53 pathway | 112 | 28 (25%) | 2.5203888 | <2.10‐4 |
| Apoptosis | 98 | 26 (26.53%) | 2.4833248 | <2.10‐4 |
| Hypoxia | 118 | 33 (27.97%) | 2.4749684 | <2.10–4 |
| UV response up | 96 | 31 (32.29%) | 2.425803 | <2.10‐4 |
| In the blood | ||||
| Hypoxia | 118 | 42 (25.59%) | 1.9014156 | 7.0 .10‐4 |
| TNF‐α signaling via NF‐κB | 108 | 37 (34.36%) | 1.8912005 | 8.0E‐4 |
| IL6 JAK STAT3 signaling | 43 | 20 (46.5%) | 1.8102732 | 0.0035 |
| Inflammatory response | 110 | 35 (31.82%) | 1.7960621 | 0.0046 |
| Hedgehog signaling | 24 | 10 (41.67%) | 1.7309599 | 0.0162 |
NES, normalized enrichment score; GSEA, Gene Set Enrichment Analysis 10; FWER, Family‐wise error rate.