Table 1.
Preservation of differential co‐expression networks
| Tissue Origin | Histopathology | Data source | Tissue | Z summary score M1 | Z summary score M2 |
|---|---|---|---|---|---|
| Neural | Malignant | TCGA | WHO grade III IDH1wt astrocytoma | 26.8 | 46.5 |
| Neural | Malignant | TCGA | WHO grade II IDH1mut 1p/19q codeleted oligodendroglioma | 63.3 | 48.8 |
| Neural | Malignant | TCGA | WHO grade III IDH1mut 1p/19q codeleted oligodendroglioma | 16.4 | 18.9 |
| Neural | Malignant | TCGA | Glioblastoma | 23.0 | 67.1 |
| Neural | Malignant | GEO | Glioblastoma (GSE77530) | 12.8 | 29.9 |
| Neural | Malignant | GEO | Glioblastoma (non‐enhancing) (GSE59612) | 30.0 | 18.9 |
| Neural | Malignant | GEO | Glioblastoma (enhancing) (GSE59612) | 3.7 | 45.9 |
| Nonneural | Malignant | TCGA | Colon adenocarcinoma | 0.8 | 33.8 |
| Nonneural | Malignant | TCGA | Liver hepatocellular carcinoma | 1.4 | 58.8 |
| Nonneural | Malignant | TCGA | Lung adenocarcinoma | 2.0 | 101.9 |
| Nonneural | Nonmalignant | GTEx | Colon | 1.1 | 15.0 |
| Nonneural | Nonmalignant | GTEx | Lung | 0.5 | 16.6 |
| Nonneural | Nonmalignant | GTEx | Liver | 0.1 | 6.9 |
| Neural | Nonmalignant | GTEx | Cerebral cortex | 11.8 | –1.3 |
Preservation of modules M1 and M2 in neural and non‐neural malignant and non‐cancerous tissues assessed by the composite network preservation statistic Z summary.30 Z summary scores >10 represent strong evidence for preservation, Z summary < 2 is interpreted as no preservation and Z summary 2–10 suggests weak to moderate preservation. LGA expression was used as the reference set to investigate M1 preservation and AA to explore module M2 preservation in other datasets.