Figure 2.

Metformin improved coordinated running and balance performance in young male normoglycemic mice. Session wise (A) and learning index and maximum performance (B) of rotarod test demonstrated metformin treatment improved coordinated running. Wire suspension test demonstrated that metformin did not affect motor reflex (C) and muscle strength (D). Bridge walking test demonstrated that metformin treatment improved balance performance (E & F). Session wise performance and (E) and session 4 and average of balance beam test (F) in bridge walking test. Each value represents mean ± SEM, n=10. * p<0.05 vs control.