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. 2019 Oct 1;10(5):949–963. doi: 10.14336/AD.2019.0120

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Copyright: © 2019 Li et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Metformin treatment altered metabolomic profile in hippocampus of young male normoglycemic mice. A) Heatmap of 145 metabolites (Supplementary Table) in mice hippocampus after 7-day treatment with metformin in drinking water (2mg/ml). B) Metformin treatment significantly increased levels of dimethylglycine, histidine, and choline in the hippocampus. Significant decreased levels of malic acid, thymidine, dihydroxyacetone-phosphate (DHAP), and myo-inositol were observed in the hippocampus of metformin-treated mice (* p<0.05) (n=4).