Table 1.
Baseline characteristics
| Variable | Overall (n = 1596) |
IGFBP‐2 T1 (n = 531) |
IGFBP‐2 T2 (n = 533) |
IGFBP‐2 T3 (n = 532) |
|---|---|---|---|---|
| No. (%) | ||||
| Age, year, mean (SD) | 68.7 (5.7) | 66.7 (4.8) | 68.4 (5.5) | 71.0 (5.9) |
| Women | 841 (52.7) | 289 (54.4) | 265 (49.7) | 287 (54.0) |
| Systolic blood pressure, mmHg, mean (SD) | 132.4 (19.2) | 132.3 (17.3) | 132.0 (19.6) | 132.9 (20.6) |
| BMI, kg/m2, median (Q1, Q3) | 28.1 (24.7, 30.9) | 29.5 (26.7, 32.8) | 27.5 (25.0, 30.8) | 25.7 (23.2, 28.3) |
| IGFBP‐2, pg/mL, median (Q1, Q3) | 1.2 × 107 (8.2 × 106, 1.8 × 107) | 6.7 × 106 (5.3 × 106, 8.2 × 106 | 1.2 × 107 (1.1 × 107, 1.4 × 107 | 2.1 × 107 (1.8 × 107, 2.6 × 107) |
| Education | ||||
| No high school degree | 101 (6.5) | 29 (5.7) | 28 (5.4) | 44 (8.5) |
| High school degree | 525 (33.9) | 182 (35.6) | 168 (32.3) | 175 (33.8) |
| Some years of college | 450 (29.0) | 145 (28.3) | 151 (29.0) | 154 (29.7) |
| College degree | 475 (30.6) | 156 (30.5) | 174 (33.4) | 145 (28.0) |
| Antihypertensive medication | 700 (43.9) | 240 (45.3) | 230 (43.2) | 230 (43.2) |
| Current smoker | 135 (8.5) | 27 (5.1) | 47 (8.8) | 61 (11.5) |
| Prevalent diabetes mellitus | 262 (16.4) | 114 (21.5) | 84 (15.8) | 64 (12.0) |
| ApoE4 allele | 353 (22.4) | 120 (23.1) | 122 (23.0) | 111 (21.2) |
| Prevalent CVD | 302 (18.9) | 73 (13.8) | 97 (18.2) | 132 (24.8) |
| Atrial fibrillation | 94 (5.9) | 23 (4.3) | 37 (6.9) | 34 (6.4) |
| Stroke | 42 (2.6) | 10 (1.9) | 10 (1.9) | 22 (4.1) |
Baseline demographic and clinical characteristics were defined at examination 7. IGFBP‐2, insulin‐like growth factor binding protein‐2; SD, standard deviation; BMI, body mass index; CVD, cardiovascular disease; APOE E4, apolipoprotein E4 allele.