Table 2.
IGFBP‐2 and risk of incident dementia and AD dementia
| Model | Dementia | Alzheimer’s disease | |||
|---|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | ||
| Per SDU increase | 1 | 1.48 (1.21–1.82) | 0.0002 | 1.53 (1.21–1.94) | 0.0004 |
| 2 | 1.57 (1.27–1.93) | <0.001 | 1.58 (1.24–2.01) | 0.0002 | |
| 3 | 1.56 (1.25–1.95) | <0.001 | 1.56 (1.21–2.02) | 0.0006 | |
| Tertile 1 | 1 | Reference | Reference | ||
| Tertile 2 | 1.71 (0.99–2.97) | 0.056 | 2.44 (1.23–4.85) | 0.01 | |
| Tertile 3 | 2.50 (1.48–4.23) | 0.0006 | 3.17 (1.62–6.19) | 0.0007 | |
| Tertile 1 | 2 | Reference | Reference | ||
| Tertile 2 | 1.87 (1.07–3.26) | 0.03 | 2.71 (1.36–5.42) | 0.005 | |
| Tertile 3 | 2.90 (1.68–5.00) | 0.0001 | 3.72 (1.86–7.42) | 0.0002 | |
| Tertile 1 | 3 | Reference | Reference | ||
| Tertile 2 | 1.87 (1.07–3.27) | 0.029 | 2.68 (1.33–5.40) | 0.006 | |
| Tertile 3 | 2.89 (1.63–5.13) | 0.0003 | 3.63 (1.76–7.50) | 0.0005 | |
Model 1: adjusted for age and sex. Model 2: adjusted for model 1 + education, systolic blood pressure, use of antihypertensive medication, prevalent cardiovascular disease, prevalent diabetes mellitus, and ApoE4 carrier status. Model 3: adjusted for model 2 + BMI. IGFBP2 was natural logarithmically transformed and standardized. IGFBP‐2, insulin‐like growth factor binding protein‐2; SDU, standard deviation unit; HR, hazard ratio; CI, confidence interval.