Table 3.
IGFBP‐2 and risk of incident dementia and AD dementia, excluding those with prior stroke
| Model | Dementia | Alzheimer’s disease | |||
|---|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | ||
| Per SDU increase | 1 | 1.58 (1.28–1.95) | <0.0001 | 1.65 (1.29–2.11) | <0.0001 |
| 2 | 1.72 (1.38–2.15) | <0.0001 | 1.77 (1.37–2.29) | <0.0001 | |
| 3 | 1.70 (1.35–2.14) | <0.0001 | 1.74 (1.33–2.27) | <0.0001 | |
| Tertile 2 | 1 | 1.90 (1.06–3.43) | 0.03 | 2.79 (1.32–5.89) | 0.007 |
| Tertile 3 | 2.87 (1.63–5.05) | 0.0003 | 3.83 (1.85–7.93) | 0.0003 | |
| Tertile 2 | 2 | 1.97 (1.09–3.58) | 0.03 | 2.89 (1.36–6.15) | 0.006 |
| Tertile 3 | 3.25 (1.81–5.83) | <0.0001 | 4.37 (2.06–9.27) | 0.0001 | |
| Tertile 2 | 3 | 1.94 (1.06–3.53) | 0.04 | 2.81 (1.31–6.02) | 0.008 |
| Tertile 3 | 3.12 (1.69–5.75) | 0.0003 | 4.13 (1.89–9.01) | 0.0004 | |
Model 1: adjusted for age and sex. Model 2: adjusted for model 1 + education, systolic blood pressure, use of antihypertensive medication, prevalent cardiovascular disease, prevalent diabetes mellitus, and ApoE4 carrier status. Model 3: adjusted for model 2 + BMI. IGFBP2 was natural logarithmically transformed and standardized. Reference for tertiles is the lowest tertile. IGFBP‐2, insulin‐like growth factor binding protein‐2; SDU, standard deviation unit; HR, hazard ratio; CI, confidence interval.