Table 6.

Model discrimination and risk reclassification

	Dementia				Alzheimer’s
	C‐statistic (95% CI)	Relative IDI (95% CI)	Overall NRI (95% CI)	NRI, events NRI, nonevents*	C‐statistic (95% CI)	Relative IDI (95% CI)	Overall NRI (95% CI)	NRI, events NRI, nonevents*
Model 2	0.81 (0.77–0.85)	–	–	–	0.85 (0.82–0.88)	–	–	–
Model 2 + I GFBP‐2	0.82 (0.79–0.86)	0.15 (0.07–0.23)	0.40 (0.22–0.59)	0.32 0.08	0.87 (0.84–0.90)	0.13 (0.05–0.22)	0.42 (0.20–0.65)	0.34 0.08

Model 2: adjusted for age, sex, education, systolic blood pressure, use of antihypertensive medication, prevalent cardiovascular disease, prevalent diabetes mellitus, and ApoE4 carrier status. IGFBP‐2 was natural logarithmically transformed and standardized. IDI, integrated discrimination improvement; NRI, net reclassification improvement.

^*Proportion of events correctly reclassified. Proportion of nonevents correctly reclassified.