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. 2019 Sep 27;14(9):e0222587. doi: 10.1371/journal.pone.0222587

Fig 4. Transplantation of NRG1-AdMSCs activates ErbB4-associated downstream signaling pathways.

Fig 4

(A) Representative western blot of three independent experiments results of ErbB4, MAPK, pMAPK, Akt, and pAkt. (B) Graphs showing relative expression levels of ErbB4, MAPK, pMAPK, AKT, and pAKT among PBS-, AdMSCs-, and NRG1-AdMSCs-treated groups. Expression of ErbB4, a receptor of NRG1, was markedly increased by NRG1-AdMSCs treatment (PBS, n = 7; AdMSCs, n = 8; NRG1-AdMSCs, n = 8). Moreover, pMAPK and pAkt expressions were significantly increased by NRG1-AdMSCs transplantation, compared to PBS-treated controls (PBS, n = 7; AdMSCs, n = 10; NRG1-AdMSCs, n = 10). *p < 0.05 by one-way ANOVA followed by LSD post hoc test. The data are presented as the mean ± SEM.