Figure 2. Tau preferentially deposits within regions of functional connectivity (FC) with entorhinal cortex.
Tau deposition, defined as the proportion of suprathreshold FTP voxels (>1.4 SUVR), was measured in each FC mask and in cortical regions that did not demonstrate FC with the seeds (‘Outside’). Tau deposition in each region was contrasted with repeated measures ANCOVAs and post-hoc t-tests. (a) Tau preferentially deposited within regions of EC FC (green) compared to outside cortical regions (gray). Region by Aβ status interactions were driven by an increased mean difference between the EC and outside cortical regions in the Aβ+ compared to the Aβ- group. (b) Tau preferentially deposited within regions of alEC FC (red) compared to both pmEC FC (blue) and outside cortical regions (gray), and in pmEC FC compared to outside cortical regions. Region by Aβ status interactions were driven by an increased mean difference between alEC FC and outside cortical regions in the Aβ+ compared to the Aβ- group. See Figure 2—figure supplement 1 for parallel results using OA FC. ***p<0.001, **p<0.01, *p<0.05; ‘x’ indicates the drivers of significant Aβ status interactions (p<0.05); Error bars indicate the standard error of the mean.
Figure 2—figure supplement 1. Tau deposition within regions of functional connectivity (FC) with entorhinal cortex derived from FC from the older adult (OA) participants.
