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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Arthritis Rheumatol. 2019 Sep 2;71(10):1701–1710. doi: 10.1002/art.40898

Table 2.

Genes for profiling molecular pathways enriched in each intrinsic subset were selected using the ranked positive, non-zero coefficients in the final model.

Subset Summary of Significant Biological Processes (g:SCS corrected p< 0.05, g:Profiler) Select Genes
Inflammatory Response to stress, response to wounding, immune system process, inflammatory response, defense response, angiogenesis CD33, CD52, CXCL2, CXCR4, CXCR3, CTGF, FN1, IL6, THBS1, COL11A1, COL8A2, VCAM1, SYK, SPHK1
Fibroproliferative Metabolic process, cellular metabolic process, ncRNA metabolic process, mitochondrial gene expression CENPV, CXCL1, COMP, POLR1B, SPIN2B, MTOR, ALAD, TSFM, ELAC2
Normal-like Electron transport chain, cellular respiration SP5, COX5B, NDUFV3, GPD2, ETFA
Limited Actin filament depolymerization FBLN1, STAT6, TRIM46, SPTBN1, GSN, VILL