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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: Curr Pharm Des. 2019;25(19):2199–2206. doi: 10.2174/1381612825666190618124829

Figure 1. Increased esmolol dose restores esmolol-cardioprotection in epinephrine-esmolol co-administration during myocardial ischemia and reperfusion injury.

Figure 1.

C57BL/6J wildtype mice underwent 60 min of myocardial ischemia followed by 120 minutes of reperfusion. Wildtype mice received either saline, esmolol (0.4mg/kg/h), epinephrine (0.05 mg/kg/h), or esmolol combined with epinephrine (esmolol: 0.4 mg/kg/h or 0.8 mg/kg/h and epinephrine: 0.05 mg/kg/h) during 120 min of reperfusion. Infarct sizes were determined by using standard double staining with Evan’s blue and TTC (triphenyl-tetrazolium chloride). The percent of the area at risk (AAR) that underwent infarction indicates the infarct size. (A) Infarct sizes as the percent of AAR. (B) Representative infarct staining (n=6; mean±SD; p<0.05).