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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: Curr Pharm Des. 2019;25(19):2199–2206. doi: 10.2174/1381612825666190618124829

Figure 3. Comparison of heart rates.

Figure 3.

C57BL/6J mice were anesthetized with pentobarbital and mechanically ventilated. The common carotid artery was cannulated with a polyethylene tube. The arterial catheter was then connected to a pressure transducer which automatically calculated the heart rate (HR) by analyzing the amplitude of the pressure signal. Values were recorded to computer hard drive for further analysis. Mice underwent 60 min of myocardial ischemia followed by 120 minutes of reperfusion. During reperfusion, mice received either saline, esmolol (0.4mg/kg/h), epinephrine (0.05 mg/kg/h), or esmolol combined with epinephrine (esmolol: 0.4 mg/kg/h or 0.8 mg/kg/h and epinephrine: 0.05 mg/kg/h). HR was recorded during the whole procedure; (n=6; mean±SD; p<0.05).