Fig. 2–

49-year-old man with hereditary hemochromatosis. Rapid fat and iron chemical shift–encoded MRI protocol shows mild hepatic iron overload. R2* map (right) shows elevated R2* of 134 s⁻¹ (normal, < 120 s⁻¹ at 3 T) as measured in posterior right hepatic lobe. Proton density fat fraction (PDFF) map (middle) shows that PDFF is normal at 4% (normal, < 5%). Axial T2-weighted single-shot fast spin-echo MR image (left) is shown for reference. Note cirrhotic configuration of liver and T2 hypointensity of liver parenchyma due to increased iron, as well as lower R2* signal in spleen (S, right), indicative of normal iron content, which is typical pattern of iron overload in patients with hemochromatosis. Circles denote ROIs.