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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: DNA Repair (Amst). 2019 Jul 8;81:102661. doi: 10.1016/j.dnarep.2019.102661

Figure 5. Possible functions of RNA:DNA hybrids during DSB repair.

Figure 5.

RNA:DNA hybrids formed around the break could serve: 1. as a platform to recruit DSB repair proteins; 2. to produce DNA damage response RNAs (DDRNAs); 3. as a template for a RNA-mediated repair mechanism 4. to control resection and single-strand binding proteins assembly, thereby regulating downstream events such as Rad51 nucleofilament assembly and homologous recombination.