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. 2019 Sep 27;10:4397. doi: 10.1038/s41467-019-12292-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — miR-574-5p and -3p divergently control GC cell growth and metastasis. a The effects of miR-574-5p/-3p overexpression on GC cell (MGC-803 and HGC-27) proliferation (left), colony formation ability (middle), and early apoptosis (right). Three technical replicates from a single experiment representative of three independent experiments. b Photographs of MGC-803-engrafted tumors treated with scramble or miR-574-5p/-3p mimics at the end of the experiment (day 40), and tumor volumes as well as tumor weight are shown at the indicated days (n = 4). c Immunohistochemistry analysis of Ki-67 and caspase-3 expression in tumors from xenograft mice. d Bioluminescence imaging of mice showed GC cell metastasis in vivo and H&E staining of the lung tissues. e The relative percent of metastatic nodules formation in lung. f The survival rate of mice transplanted with MGC-803 cells treated with scramble or miR-574-5p/-3p mimics. Data are shown as means ± s.d. *p < 0.05, **p < 0.01, ***p < 0.001, Student’s t-test.