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. 2019 Sep 27;10:4033. doi: 10.1038/s41467-019-12052-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Targeted inhibition of virus multiplication by dsRNases fused with host factors involved in viral RNA replication. a Working model for targeted inhibition. By fusing a dsRNase (dR) with host factors (HF) included in the viral replication complex, dsRNase is delivered into the replication compartment. b Inhibition of multiplication of three different viruses by dsRNases designed to target the replication complexes of each virus. Accumulation of coat proteins (CP) in inoculated leaves was examined by Coomassie staining (ToMV and CMV) or western blotting (TuMV) at 2–4 dpi. The RTL2 (D100A) constructs contain a catalytic mutation in RTL2. The source data of Fig. 6b are provided as a Source Data file