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. 2019 Sep 27;10(10):725. doi: 10.1038/s41419-019-1916-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Transmission electron microscopy (TEM) revealed a dose-dependent increase in vacuolization in MPM cells after PFK158 treatment (0–10 μM) in H28 and EMMeso cells. b Phase contrast microscopic and c, d TEM pictures of increased vacuoles in PFKFB3 knockdown clones (sh55 and sh59) in comparison to non-targeted control (NTC). e and f Augmented macropinocytosis visualized by Dextran-10K uptake after PFK158 treatment both in H28 and Meso. g PFKFB3 knockdown H28 clones also demonstrated extensive macropinocytosis by Dextran-10K uptake