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. 2019 Sep 27;10:4429. doi: 10.1038/s41467-019-12387-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — NMDARs in NAc are necessary for the acquisition of cued approach behavior. a Task. ITI: intertrial interval. b Microinjection schedule. VEH: vehicle. c “Yoking” procedure (sample session). Each AP5/VEH or VEH/VEH subject is identified by a letter. Bubbles indicate trials during which subjects made a cued entry (black) or not (white). Red boxes indicate trials when the receptacle was closed. d Mean ± SEM number of “Paired” (black) and “unpaired cue” trials (white) experienced on each session by the AP5/VEH or VEH/VEH group. Red bars indicate trials during which the receptacle was closed. Both groups experienced the same number of “paired” and “unpaired cue” trials daily. e Mean ± SEM S+ entry probability in the VEH/VEH (blue) and AP5/VEH (red) groups on the test (drug-free) session (whole session, left; first 5 min, right). No rewards were delivered. There were main effects of the drug, bin and drug × bin interaction (Supplementary Table 1). Box plots show median, interquartile range, and individual values. S+ entry probability was lower in previously AP5-treated subjects (***p < 0.001, t test). f Same as in e but for S+ performance index. There were main effects of drug and drug × bin interaction. During the first 5 min, animals that received AP5 injections during training exhibited lower S+ performance index (***p < 0.001; t test)