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. 2019 Sep 27;10(10):727. doi: 10.1038/s41419-019-1908-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic displaying the application of uniaxial strain injury. A linear actuator drives a syringe piston to apply pneumatic actuation and inject pressure into the cavity beneath the interconnecting microchannels. Injected pressure is read using a high-speed analog to digital converter. b Strain modeling in MATLAB, PDE Toolbox. Application of 2.0 psi induces a deflection of 300 μm in 2-mm-wide pneumatic channel (15% strain). c Phase-contrast micrographs of processes before and ~1 min after application of 15% strain injury. d Fluorescence micrographs of mitochondria (labeled with MitoTracker Green FM) within interconnecting microchannels before and after application of 15% strain injury. e Phase-contrast micrographs of axonal processes before and 2 and 15 h after application of 15% strain injury. Scale bars, 25 μm, 10 μm (c), 25 μm, 10 μm (d), 50 μm (e)