Fig. 6.

Insulin targets in VSMCs. a The expression of insulin-targeted genes in aorta media of WT and SMIRKO mice. RNA was extracted from aorta media of WT and SMIRKO mice and the expression levels of genes were determined by qPCR (WT Has2, n = 5; SMIRKO Has2, n = 6; n = 3 for each of the remaining groups). b The expression of Has2 protein in aorta media of WT and SMIRKO mice (WT, n = 3; SMIRKO, n = 4). c The expression of insulin-targeted genes in aorta media of WT and SMIGF1RKO mice. RNA was extracted from aorta media of WT and SMIGF1RKO mice, and the expression levels of genes were determined by qPCR (n = 3 per group). d The expression of Has2 protein in aorta media of WT and SMIGF1RKO mice (n = 3 per group). The data are mean ± SEM. Two-tailed t test. Source data are provided as a Source Data file