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. 2019 Sep 27;10:4418. doi: 10.1038/s41467-019-12142-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — In vivo imaging. a Real-time MRI of KB tumor-bearing mice after intravenous injection of ICG@Fe/FeO–PPP nanocapsules and ICG@Fe/FeO–PPP–FA nanocapsules. b The relative MRI signal intensities changing at the tumor site after intravenous injection of ICG@Fe/FeO–PPP nanocapsules and ICG@Fe/FeO–PPP–FA nanocapsules, respectively. c Real-time fluorescence images of tumor-bearing mice after intravenous injection of ICG@Fe/FeO–PPP nanocapsules and ICG@Fe/FeO–PPP–FA nanocapsules. Ex vivo fluorescence images of liver (1), spleen (2), lung (3), heart (4), kidney (5) and tumor (6), which were obtained at 48 h post-injection. d The fluorescence intensities of the major organs after intravenous injection of ICG@Fe/FeO–PPP nanocapsules and ICG@Fe/FeO–PPP–FA nanocapsules, respectively. P values in b and d were calculated by Tukey’s post-hoc test (**P < 0.01, ***P < 0.001) by comparing ICG@Fe/FeO–PPP nanocapsules with ICG@Fe/FeO–PPP–FA nanocapsules. Error bars, mean ± SD (n = 5)