Fig. 6.

Therapeutic effect of DOX–ICG@Fe/FeO–PPP–FA nanocapsules. a Schematic illustration of DOX–ICG@Fe/FeO–PPP–FA nanocapsules-based tumor therapy. b Real-time thermal IR images of KB tumor-bearing mice after intravenous injection of DOX–ICG@Fe/FeO–PPP nanocapsules and DOX–ICG@Fe/FeO–PPP–FA nanocapsules under 808 nm laser irradiation (0.3 W cm⁻², 5 min). c Volume change of tumor in the different treatment (five mice per group). d Body weight change of mice in the different treatment (five mice per group). e Representative photograph of excised tumors from euthanatized mice at 18 days post treatment (five mice per group). f H&E-stained images of tumor regions with different treatments after 2 days of intravenous injection (scale bars: 50 μm). P values in c were calculated by Tukey’s post-hoc test (**P < 0.01, ***P < 0.001) by comparing other groups with the last group (DOX–ICG@Fe/FeO–PPP–FA + Laser). Error bars, mean ± SD (n = 5)