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Illustration based on longitudinal MCT model that explains the selection of early time-points for the study. Early time-points for this model are indicated in green, where RVSP is slightly raised but without compensatory effect from the heart. Late pulmonary hypertension (red) is showed as a pronounced increase in both RVSP and Fulton index. MCT, monocrotaline; PH, pulmonary hypertension; RVSP, right ventricular systolic pressure. Color images are available online.
