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. 2019 Aug 8;47(18):9789–9802. doi: 10.1093/nar/gkz686

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — ZIKV genome circularization inhibits translation initiation. Toeprinting analysis of 48S complex assembly on WT capped ZIKV^mini RNA and (A) ΔCS mutants, (B) ΔUAR mutants, (C) in the presence of scrambled (SCR) or anti-sense (ASO) RNA oligos and (D) upstream near-cognate codon mutants highlighted in red in the schematic on the left. Selected codons are labelled on the left of each gel and toeprints caused by 48S complex assembly are marked with a closed arrowhead on the right. Open arrowheads mark reverse transcriptase stops caused by hybridization of the 5′ and 3′ cyclization elements. FL, full-length. See also Supplementary Figure S3.