Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 8;47(18):9789–9802. doi: 10.1093/nar/gkz686

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — Model for the control of translation initiation by genome circularization. Linear genomic RNA recruits eIFs and 40S ribosomal subunits (pale grey) in a cap-dependent manner. Secondary structure in the 5′ UTR is effectively resolved by helicase eIF4A to allow translation initiation from the authentic initiation codon, indicated by a green 48S complex. Following genome circularization, promoted by viral and host factors (64–68) and likely occurring at the ER membrane, scanning ribosomes are impeded by extensive RNA structure formed by hybridization of 5′ and 3′ cyclization elements. Decreased translation from the authentic AUG permits efficient genome replication by NS5^pol (purple).