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. 2019 Jul 30;47(18):e112. doi: 10.1093/nar/gkz656

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Illustration of the ARACNE step (the width of the links represents the interaction strength): (A) true interaction structure: Z is strongly linked to X and Y, which are not directly linked to each other. (B) A pairwise test outputs a significant association between X and Y due to the indirect link through Z. (C) The ARACNE step removes the indirect link between X and Y, being the weakest out of the three links.