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. 2019 Aug 10;47(18):9857–9870. doi: 10.1093/nar/gkz701

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Hyperaccurate and error-prone ribosomes suppress and amplify the effects of 8-oxoG, respectively (A–D) Representative time courses of peptide-bond formation between the indicated initiation and ternary complexes with the depicted ribosome mutant. The time courses shown on the right panel were carried out with the unmodified complex, whereas ones shown on the left panel were carried out with the modified complex (8-oxoG drawn in red). Time courses were conducted at least in duplicates for constructs containing 8-oxoG; the fold difference was reproducible.