Table 4. Cellular toxicity pathways implicated by predicted targets of miR 29c-3p, miR 584-5p, and miR 1247-5p.
| Ingenuity toxicity pathway | -log (P-value) | Ratio | Gene |
|---|---|---|---|
| Cardiac necrosis/cell death | 3.75 | 0.068 | FNG, THBS4, LEP, LIF, PPIF, UBE4B, TNFAIP3, MDM2, KRAS, DICER1, THBD, THBS2, PRKAA1, WISP1, NAMPT, GSK3B, CDK2, MCL1, CALCA, PPARGC1A |
| p53 signaling | 3.61 | 0.0982 | AKT2, TP53INP1, CCND2, TP63, GAB1, PIK3CG, PIK3R1, HDAC1, MDM2, GSK3B, CDK2 |
| Renal necrosis/cell death | 3.23 | 0.0527 | PTHLH, EMP2, NF2, TNFAIP3, KRAS, PKN2, NFAT5, PRKAA1, NAMPT, PPM1A, AMER1, GNA13, GSK3B, CALB1, ZNF512B, MCL1, TRAF1, ITGB1, IFNG, TP53INP1, FOS, PEX5, GLIS2, CDC42, TMX1, CALCR, CDK2, CALCA, BIRC2 |
| TGF-b signaling | 2.91 | 0.0938 | RAP2A, FOS, RUNX2, CDC42, BMPR1A, HDAC1, TGFB2, KRAS, TAB1 |
| TR/RXR activation | 2.85 | 0.0918 | AKT2, GAB1, COL6A3, PIK3CG, PIK3R1, MDM2, G6PC, PPARGC1A, NCOA4 |
| Anti-apoptosis | 2.79 | 0.156 | HDAC1, TMX1, TNFAIP3, MCL1, BIRC2 |
| Hepatic fibrosis | 2.64 | 0.0857 | IFNG, LEP, COL6A3, COL4A3, THBS2, TGFB2, PDGFB, AHR, NID1 |
| Cell cycle: G1/S checkpoint regulation | 2.57 | 0.101 | CCND2, HDAC1, CDK6, TGFB2, MDM2, GSK3B, CDK2 |
| Cardiac fibrosis | 2.2 | 0.0605 | PTX3, ITGB1, IFNG, TRDN, TNFAIP3, CACNA1C, DICER1, NF1, BMPR1A, THBS2, GSK3B, DAG1, AHR |
| VDR/RXR activation | 1.71 | 0.0769 | IFNG, RUNX2, MXD1, TGFB2, CALB1, THBD |
| Liver necrosis/cell death | 1.63 | 0.0484 | IFNG, LIF, PIK3R1, DICER1, PDGFB, NPC1, FOS, NF1, PIK3CG, G6PC, GSK3B, AHR, PPARGC1A, BIRC2, MCL1 |
| Increases renal nephritis | 1.63 | 0.0833 | IFNG, LEP, LIF, TRAF3IP2, COL4A3 |
| Liver proliferation | 1.49 | 0.05 | ITGB1, IFNG, FOS, LEP, NFATC3, PIK3R1, HDAC1, PRKAA1, DICER1, GSK3B, CDK2, AHR |
| Primary glomerulonephritis biomarker panel (human) | 1.46 | 0.182 | SAMD4A, MCL1 |
| NF-kB signaling | 1.39 | 0.0469 | RAP2A, IL36G, AKT2, TRAF3, GAB1, BMPR1A, PIK3CG, PIK3R1, HDAC1, TNFAIP3, KRAS, GSK3B, TAB1 |
| Mechanism of gene regulation by peroxisome proliferators via PPARa | 1.34 | 0.0632 | FOS, PIK3R1, KRAS, PDGFB, TAB1, PPARGC1A |
| Increases cardiac proliferation | 1.33 | 0.08 | LEP, BMPR1A, WISP1, DICER1 |
| Increases renal proliferation | 1.3 | 0.0541 | ITGB1, PTHLH, YBX3, WISP1, RNF144B, PTP4A1, PDGFB, CDK2 |
| Decreases depolarization of mitochondria and mitochondrial membrane | 1.25 | 0.0938 | CSTB, MCL1, PPARGC1A |
TGF-b: Transforming growth factor-b