Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 6;12(9):dmm040386. doi: 10.1242/dmm.040386

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 1. — Important challenges in understanding the biology of GBM. GBM stem cells exist in various states (dormant/quiescent, activated/quiescent or proliferative) that are influenced by diverse tumour microenvironments (TMEs). Complex niches, immune interactions and physical forces/mechanosignalling are all poorly understood areas of GBM biology. How these influence tumour cell signalling circuits and the subsequent transcriptional and epigenetic changes in GSC fate is an area of active research. Targeting both the quiescent and proliferative tumour populations will be vital for any successful therapeutic strategy.