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. 2019 Sep 24;12(9):dmm040550. doi: 10.1242/dmm.040550

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Anxiety behaviours in 8-month-old App^NL-G-F KI mice in the open field (OF) and elevated plus maze (EPM). (A) Given 30 min free ambulation, all genotypes expressed similar amounts of locomotor activity as quantified by distance travelled. (B,C) App^NL-G-F KI mice displayed thigmotaxis in the OF, spending significantly more time against the walls (B) and less time in the centre zone (C). (D,E) Conversely, App^NL-G-F KI mice spent significantly more time exploring the open arms of the EPM (D) and significantly less time within the closed arms (E), suggesting an anxiolytic profile. All statistics used two-way ANOVAs. ***P<0.001, **P<0.01, *P<0.05. Error bars are s.e.m. Wild-type n=21, App^NL-G-F KI n=19.