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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Mol Pharm. 2019 Jul 31;16(9):3904–3915. doi: 10.1021/acs.molpharmaceut.9b00512

Figure 1.

Figure 1.

MC1R-targeted ligands DOTA-MC1L. [203/212Pb]DOTA-MC1L shares the His-D-Phe-Arg-Trp sequence (blue) moiety for receptor binding and is labeled with 203/212Pb radionuclides (red). γ emitter 203Pb was used for SPECT/CT imaging, and α-particle emitter 212Pb was applied for α-radiation therapy.