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. 2019 Sep 5;116(39):19665–19674. doi: 10.1073/pnas.1907631116

Fig. 1.

Fig. 1.

Clinical M. tuberculosis isolates with mixtures of small smooth and large rough colonies. Initial cultures of (A) pan susceptible M. tuberculosis strain C71 and (B) multidrug-resistant M. tuberculosis strain TDR193 were plated on 7H10 agar containing glycerol. (C) The glpK slippage site sequences of LCs and SCs are shown. (D) C71-LC showed emergence of SCs at passage 2. (E) C71-SC showed emergence of LCs at passage 2. (F) Emergence at passage 4 and accumulation of LCs at (G) passage 11 of a TDR193-SC culture. (H) TDR193-LC phenotype was stable after 12 passages. Examples of SCs are indicated by red arrows and LCs by black arrows.