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. 2019 Sep 5;116(39):19665–19674. doi: 10.1073/pnas.1907631116

Fig. 2.

Fig. 2.

Frameshift glpK mutants develop in M. tuberculosis-infected mice and are less susceptible to antituberculosis treatment. (A) BALB/c mice were infected by aerosol with M. tuberculosis HN878 strain and treated with MXF (100 mg/kg) over 1 wk, as indicated by red arrows. Shown are the averages and SDs of CFU per lung of 4 to 5 mice killed at the indicated time points. (B) Small smooth colonies isolated from an infected mouse lung after 1 wk of MXF treatment. Examples of SCs are indicated by red arrows. (C) Frequency, in percentage (%), of SC in the control and MXF-treated groups of 4 mice each. Significant difference in frequency was determined by 2-tailed Student’s t test.