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. 2019 Sep 5;116(39):19665–19674. doi: 10.1073/pnas.1907631116

Fig. 3.

Fig. 3.

Decreased susceptibility of glpK mutants to various antituberculosis drugs. Differential susceptibility of (A) TDR193 and (B) HN878 LC and SC variants to sub-MIC concentrations of MXF, EMB, INH, and RIF were determined by percent survival of CFU on 7H10 medium containing the antibiotic at the indicated concentrations versus no antibiotic control CFU. Differential susceptibilities of H37Rv WT, H37RvΔglpK, and H37RvΔglpK::glpK to sub-MIC concentrations of (C) INH, (D) RIF, and (E) MXF compared to no antibiotic control were determined by OD600 measurements. (F) Susceptibility of H37Rv WT, H37RvΔglpK, and H37RvΔglpK::glpK to MXF, INH, and RIF concentrations were determined by percent survival of CFU at the indicated concentrations compared to no antibiotic control. The values of 3 independent experiments are shown for each graph. Significant differences of survival frequencies were calculated using 2-tailed Student’s t test or 2-way ANOVA analysis, *P < 0.05.