Fig. 1.

Global chromatin architecture is unaltered during HS-induced transcriptional changes. (A) Schematic of datasets generated and analyzed in this study. Human K562 or Drosophila S2 HS and NHS cells were used to generate in situ Hi-C data, and these datasets were compared to corresponding PRO-seq (5, 8) and ChIP-seq (4, 7, 8) datasets denoted by asterisk. (B) Comparison of PRO-seq, in situ Hi-C, and ChIP-seq assays performed on HS and NHS K562 cells. Gray region highlights a classical HS locus containing the HSP90AB1 gene.