Fig. 4.

The miRNAs identified as contributing most to the 3 constraints. Each column is identified by the constraint index α: A and D, α = 1; B and E, α = 2; C and F, α = 3. The Top row (A–C) are expression levels of the 5 miRNAs with the most positive value of their weight, $G_{i\alpha }$ in constraint $\alpha$. The Bottom row (D–F) are the expression levels of the 5 miRNAs with the most negative value of their weight, $G_{i\alpha }$ in constraint $\alpha$. The abscissa is the oxygen pressure range over which ${\lambda }_{\alpha }\left(p\right)$ changes sign. Error bars represent the SD of 3 biological replicates.