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Model of pleiotropic virulence regulation by YhaJ in distinct pathotypes. EHEC (intestinal niche) virulence is controlled by YhaJ pleiotropically—direct activation of the T3SS and prophage-encoded NleA, and indirect enhancement of T3SS by direct repression of GadX. UPEC (extraintestinal niche) virulence is enhanced by YhaJ through directly promoting phase ON orientation of the Fim switch element, leading to T1F expression.
